期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 130, 期 2, 页码 225-230出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2008.10.007
关键词
Fluorinated surfactant; Human serum albumin; Langmuir aggregation
资金
- Natural Science Foundation of Hubei Province of China
- Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules
- Innovation Group Foundation
- Elitist Foundation of the Provincial Science & Technology Department, Hubei, China
The microphase adsorption-spectral correction (MPASC) technique was described and applied to the study of the interactions of fluorinated surfactants such as potassium perfluorooctanesulfonate (PFOS) and potassium perfluorobutanesulfonate (PFBS) with human serum albumin (HSA). Sodium octanesulfonate (SOS) was also studied as non-fluorinated surfactant. The aggregation of PFOS, PFBS and SOS obeys the Langmuir monolayer adsorption. The results show that the adsorption ratios of surfactants to HSA are PFOS:HSA = 120:1, PFBS:HSA = 205:1 and SOS:HSA = 18:1. The adsorption constants are KPFOS-HSA = 5.01 x 10(3), KPFBS-HSA = 9.79 x 10(2) and KSOS-HSA = 4.03 x 10(3). The detection limits are 2.7 mg/L for BSA using PFOS, 3.1 mg/L using PFBS and 3.1 mg/L using SOS. It was found that fluorinated surfactant exhibited stronger interaction with protein than hydrogenated one, and fluorinated surfactant with long hydrophobic chain exhibited stronger interaction with protein than that with short hydrophobic chain. Crown Copyright (C) 2008 Published by Elsevier B.V. All rights reserved.
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