期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 129, 期 5, 页码 349-358出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2008.01.011
关键词
aryltrifluoroborate; PET; synthesis; kinetics; [F-18]-labeling
The aqueous stability of aryltrifluoroborates is of importance to their use in transition metal mediated coupling reactions as well as their potential use in [F-18]-labeled aryltrifluoroborate PET imaging agents. Nevertheless, few studies have fully characterized the solvolysis of fluoride from an aryltrifluoroborate in water. Using [F-19] NMR, fluorescence and [F-18]-labeling techniques, we disclose the composition of an aryltrifluoroborate of exceptional kinetic stability with respect to solvolytic defluoridation. This work not only highlights the potential of using [F-18]-labeled aryltrifluoroborates for PET tracers, but provides a chemical platform and a general approach for evaluating the stability of other aryltrifluoroborates. (c) 2008 Elsevier B.V. All rights reserved.
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