期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 129, 期 9, 页码 743-766出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2008.06.007
关键词
Fluorinated nucleosides; Antiviral activity; Anti-cancer activity
资金
- ational Institute of Allergy and Infectious Diseases, NIH [A125899]
A number of important pharmaceuticals have been discovered and developed based on fluorinated analogs of biologically active nucleosides. The introduction of fluorine into a nucleoside structure at an appropriate position has modulated and/or improved the pharmacological properties of a molecule. The present review deals with the synthetic methodology, structural and biological implication of carbohydrate-modified fluoronucleosides. Published by Elsevier B.V.
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