期刊
ONCOLOGY REPORTS
卷 35, 期 3, 页码 1868-1874出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2015.4535
关键词
breast cancer; All-trans retinoic acid; gap junction intercellular communication; connexin 43; bystander effect
类别
资金
- Shenzhen Council for Scientific and Technological Innovation [JCYJ20130402151227177]
- Shenzhen Nanshan District Science and Technology Project [2015009]
All-trans retinoic acid (ATRA) has been shown to enhance the expression of connexin 43 (Cx43) and the bystander effect (BSE) in suicide gene therapy. These in turn improve effects of suicide gene therapies for several tumor types. However, whether ATRA can improve BSE remains unclear in suicide gene therapy for breast cancer. In the present study, MCF-7, human breast cancer cells were treated with ATRA in combination with a VEGFP-TK/CD gene suicide system developed by our group. We found that this combination enhances the efficiency of cell killing and apoptosis of breast cancer by strengthening the BSE in vitro. ATRA also promotes gap junction intercellular communication (GJIC) in MCF-7 cells by upregulation of the connexin 43 mRNA and protein in MCF-7 cells. These results indicate that enhancement of GJIC by ATRA in suicide gene system might serve as an attractive and cost-effective strategy of therapy for breast cancer cells.
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