期刊
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-LEARNING MEMORY AND COGNITION
卷 34, 期 4, 页码 791-808出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0278-7393.34.4.791
关键词
fMRI; episodic memory; hippocampus; prefrontal cortex; fusiform face area; parahippocampal place area
资金
- NIA NIH HHS [R01 AG023770-04, T32 AG000029, F32 AG029738, R01 AG011622, F32 AG029738-02, R01 AG023770, R01 AG23770, R01 AG019731-06A2, R01 AG019731] Funding Source: Medline
- NIMH NIH HHS [R01 MH070685-04, R01 MH-70685, R01 MH070685] Funding Source: Medline
To investigate the neural basis of age-related source memory (SM) deficits, young and older adults were scanned with fMRI while encoding faces, scenes, and face-scene pairs. Successful encoding activity was identified by comparing encoding activity for subsequently remembered versus forgotten items or pairs. Age deficits in successful encoding activity in hippocampal and prefrontal regions were more pronounced for SM (pairs) as compared with item memory (faces and scenes). Age-related reductions were also found in regions specialized in processing faces (fusiform face area) and scenes (parahippocampal place area), but these reductions were similar for item and SM. Functional connectivity between the hippocampus and the rest of the brain was also affected by aging; whereas connections with posterior cortices were weaker in older adults, connections with anterior cortices, including prefrontal regions, were stronger in older adults. Taken together, the results provide a link between SM deficits in older adults and reduced recruitment of hippocampal and prefrontal regions during encoding. The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation.
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