期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 209, 期 5, 页码 889-893出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20120741
关键词
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资金
- international Human Frontier Science Program Organization
- National Institute of Neurological Disorders and Stroke [K99NS075216, R37NS27036]
- Ludwig Institute for Cancer Research
Protein misfolding is common to most neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. Recent work using animal models with intracellular alpha-synuclein and tau inclusions adds decisively to a growing body of evidence that misfolded protein aggregates can induce a self-perpetuating process that leads to amplification and spreading of pathological protein assemblies. When coupled with the progressive nature of neurodegeneration, recognition of such cell-to-cell aggregate spread suggests a unifying mechanism underlying the pathogenesis of these disorders.
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