期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 209, 期 10, 页码 1841-1852出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20120219
关键词
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资金
- National Institutes of Health
- Odyssey fellowship from the University of Texas MD Anderson Cancer Center
T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program.
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