期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 208, 期 13, 页码 2733-2746出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20111155
关键词
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资金
- National Institutes of Health [AI077595, AI076210, 5P01AI076210-02, R21 CA133781, K08AI89972]
- Swiss National Science foundation (SNSF)
- American Association of Allergy Asthma and Immunology
- Burroughs Wellcome Fund
- CSL-Behring
Immunoglobulin heavy chain (IgH) class-switch recombination (CSR) replaces initially expressed C mu (IgM) constant regions (C(H)) exons with downstream C(H) exons. Stimulation of B cells with anti-CD40 plus interleukin-4 induces CSR from C mu to C gamma 1 (IgG1) and C epsilon (IgE), the latter of which contributes to the pathogenesis of atopic diseases. Although C epsilon CSR can occur directly from C mu, most mature peripheral B cells undergo CSR to C epsilon indirectly, namely from C mu to C gamma 1, and subsequently to C epsilon. Physiological mechanisms that influence CSR to C gamma 1 versus C. are incompletely understood. In this study, we report a role for B cell developmental maturity in IgE CSR. Based in part on a novel flow cytometric IgE CSR assay, we show that immature B cells preferentially switch to IgE versus IgG1 through a mechanism involving increased direct CSR from C mu to C epsilon. Our findings suggest that IgE dysregulation in certain immunodeficiencies may be related to impaired B cell maturation.
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