期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 2, 页码 273-280出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20092029
关键词
-
资金
- Institut Pasteur
- Institut National de la Sante et de la Recherche Medicale
- Equipe Labelise
- Ligue Nationale Contre le Cancer
- Association Pasteur Japon
- Uehara Memorial Foundation, Japan
The natural cytotoxicity receptor NKp46 (encoded by Ncr1) was recently shown to identify a subset of noncytotoxic, Rag-independent gut lymphocytes that express the transcription factor Rorc, produce interleukin (IL)-22, and provide innate immune protection at the intestinal mucosa. Intestinal CD3. NKp46(+) cells are phenotypically heterogeneous, comprising a minority subset that resembles classical mature splenic natural killer (NK) cells (NK1.1(+), Ly49(+)) but also a large CD127(+) NK1.1(-) subset of lymphoid tissue inducer (LTi)-like Rorc(+) cells that has been proposed to include NK cell precursors. We investigated the developmental relationships between these intestinal CD3. NKp46(+) subsets. Gut CD3. NKp46(+) cells were related to LTi and NK cells in requiring the transcriptional inhibitor Id2 for normal development. Overexpression of IL-15 in intestinal epithelial cells expanded NK1.1(+) cells within the gut but had no effect on absolute numbers of the CD127(+) NK1.1(-) Rorc(+) subset of CD3. NKp46(+) cells. In contrast, IL-7 deficiency strongly reduced the overall numbers of CD3. NKp46(+) NK1.1(-) cells that express Rorc and produce IL-22 but failed to restrict homeostasis of classical intestinal NK1.1(+) cells. Finally, in vivo fate-mapping experiments demonstrated that intestinal NK1.1(+) CD127. cells are not the progeny of Rorc-expressing progenitors, indicating that CD127(+) NK1.1(-) Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据