期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 9, 页码 1807-1817出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101157
关键词
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资金
- Nationals Institutes of Health
- American Asthma Foundation
- Goldhirsh Foundation
Everyday we turnover billions of cells. The quick, efficient, and immunologically silent disposal of the dying cells requires a coordinated orchestration of multiple steps, through which phagocytes selectively recognize and engulf apoptotic cells. Recent studies have suggested an important role for soluble mediators released by apoptotic cells that attract phagocytes (find-me signals). New information has also emerged on multiple receptors that can recognize phosphatidylserine, the key eat-me signal exposed on the surface of apoptotic cells. This perspective discusses recent exciting progress, gaps in our understanding, and the conflicting issues that arise from the newly acquired knowledge.
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