期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 7, 页码 1393-1407出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20100045
关键词
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资金
- Federal Ministry of Education and Research [FKZ 01GI0805-07]
- Deutsche Forschungsgemeinschaft (DFG
- German Research Foundation)
- FZT 111 (DFG, Center for Regenerative Therapies Dresden, Cluster of Excellence)
CD4(+)CD25(+) regulatory T cells (T reg cells) expressing the transcription factor Foxp3 can be induced from peripheral T cell receptor (TCR) transgenic CD4(+)CD25(-)Foxp3(-) T cells stimulated with noninflammatory dendritic cells presenting low amounts of agonist cognate antigen. However, limited evidence exists for extra-thymic T reg cell generation from non-TCR transgenic T cells in unmanipulated mice. We compared events early during agonist-driven generation of Foxp3(+) TCR transgenic T cells to polyclonal CD4(+) T cell populations in unmanipulated mice. We identified an interleukin-2- and phosphatidylinositol-3-kinase-dependent precommitted Foxp3(-) precursor to Foxp(3+) T reg cells in peripheral lymphoid organs. Transforming growth factor beta signaling played a minor role in the generation and subsequent differentiation of these T reg precursor cells.
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