期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 4, 页码 711-719出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20091303
关键词
-
资金
- Swiss National Foundation [PBBEB-112763]
- Human Frontier Science Program
- European Research Council
- Epigenome Network of Excellence
- Deutsche Forschungsgemeinschaft [SFB746]
- Excellence Initiative of the German federal and state governments [EXC294]
Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Ig alpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Ig alpha arginine methylation can play an important role in specifying the outcome of BCR signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据