期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 10, 页码 2097-2111出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101563
关键词
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资金
- Flemish government
- University of Ghent [GOA 01G01009]
- National Institutes of Health
- Ghent University
- EU
It is unclear how Th2 immunity is induced in response to allergens like house dust mite (HDM). Here, we show that HDM inhalation leads to the TLR4/MyD88-dependent recruitment of IL-4 competent basophils and eosinophils, and of inflammatory DCs to the draining mediastinal nodes. Depletion of basophils only partially reduced Th2 immunity, and depletion of eosinophils had no effect on the Th2 response. Basophils did not take up inhaled antigen, present it to T cells, or express antigen presentation machinery, whereas a population of FceRI(+) DCs readily did. Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen.
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