期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 5, 页码 1095-1111出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20092123
关键词
-
资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Medical Research Council [MC_U117597138] Funding Source: researchfish
- MRC [MC_U117597138] Funding Source: UKRI
Antibody affinity maturation, a hallmark of adaptive immune responses, results from the selection of B cells expressing somatically hypermutated B cell receptors (BCRs) with increased affinity for antigens. Despite the central role of affinity maturation in antibody responses, the molecular mechanisms by which the increased affinity of a B cell for antigen is translated into a selective advantage for that B cell in immune responses is incompletely understood. We use high resolution live-cell imaging to provide evidence that the earliest BCR-intrinsic events that follow within seconds of BCR-antigen binding are highly sensitive to the affinity of the BCR for antigen. High affinity BCRs readily form oligomers and the resulting microclusters grow rapidly, resulting in enhanced recruitment of Syk kinase and calcium fluxes. Thus, B cells are able to read the affinity of antigen by BCR-intrinsic mechanisms during the earliest phases of BCR clustering, leading to the initiation of B cell responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据