期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 10, 页码 2045-2048出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101866
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The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.
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