期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 207, 期 13, 页码 2843-2854出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20101098
关键词
-
资金
- Zurich Center for Integrative Human Physiology
- Swiss National Foundation [31003A-116039]
Milk oligosaccharides contribute to the development of the intestinal environment by acting as decoy receptors for pathogens and as prebiotics, which promote the colonization of commensal bacteria. Here, using alpha 2,3- and alpha 2,6-sialyltransferase-deficient mice, we investigated the role of the sialylated milk oligosaccharides sialyl(alpha 2,3)lactose and sialyl(alpha 2,6)lactose on mucosal immunity. The exposure of newborn mice to milk containing or deficient in sialyllactose had no impact on the development of mucosal leukocyte populations. However, when challenged by dextran sulfate sodium (DSS) in drinking water, adult mice that had been fostered on sialyl(alpha 2,3)lactose-deficient milk were more resistant to colitis compared with mice fostered on normal milk or sialyl(alpha 2,6)lactose-deficient milk. Analysis of intestinal microbiota showed different colonization patterns depending on the presence or absence of sialyl(alpha 2,3)lactose in the milk. Germ-free mice reconstituted with intestinal microbiota isolated from mice fed on sialyl(alpha 2,3)lactose-deficient milk were more resistant to DSS-induced colitis than germ-free mice reconstituted with standard intestinal microbiota. Thus, exposure to sialyllactose during infancy affects bacterial colonization of the intestine, which influences the susceptibility to DSS-induced colitis in adult mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据