期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 206, 期 13, 页码 2907-2914出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20091225
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [5R01AI037526, R01 AI037526, 1R0AI072529-01] Funding Source: Medline
Germinal centers (GCs) are specialized structures in which B lymphocytes undergo clonal expansion, class switch recombination, somatic hypermutation, and affinity maturation. Although these structures were previously thought to contain a limited number of isolated B cell clones, recent in vivo imaging studies revealed that they are in fact dynamic and appear to be open to their environment. We demonstrate that B cells can colonize heterologous GCs. Invasion of primary GCs after subsequent immunization is most efficient when T cell help is shared by the two immune responses; however, it also occurs when the immune responses are entirely unrelated. We conclude that GCs are dynamic anatomical structures that can be reutilized by newly activated B cells during immune responses.
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