期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 206, 期 6, 页码 1365-1378出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20090127
关键词
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资金
- ANR [JCJC06_136846, RO7119KS]
- ARC [3989, 3891, AVENIR RO4193KS]
- FRM [INE20051105133]
- INCa
- MRT fellowship
- Ligue Nationale Contre le Cancer
- INSERM AVENIR
Invariant natural killer T (iNKT) cells constitute a distinct subset of T lymphocytes exhibiting important immune-regulatory functions. Although various steps of their differentiation have been well characterized, the factors controlling their development remain poorly documented. Here, we show that TGF-beta controls the differentiation program of iNKT cells. We demonstrate that TGF-beta signaling carefully and specifically orchestrates several steps of iNKT cell development. In vivo, this multifaceted role of TGF-beta involves the concerted action of different pathways of TGF-beta signaling. Whereas the Tif-1 gamma branch controls lineage expansion, the Smad4 branch maintains the maturation stage that is initially repressed by a Tif-1 gamma/Smad4-independent branch. Thus, these three different branches of TGF-beta signaling function in concert as complementary effectors, allowing TGF-beta to fine tune the iNKT cell differentiation program.
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