期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 9, 页码 1959-1965出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20080526
关键词
-
资金
- [R01-AI50659]
- [R01-AI43576]
Mice with a T cell-specific deletion of Prdm1, encoding Blimp-1, have aberrant T cell homeostasis and develop fatal colitis. In this study, we show that one critical activity of Blimp-1 in T cells is to repress IL-2, and that it does so by direct repression of Il2 transcription, and also by repression of Fos transcription. Using these mechanisms Blimp-1 participates in an autoregulatory loop by which IL-2 induces Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled. This activity of Blimp-1 is important for cytokine deprivation induced T cell death and for attenuating T cell proliferation in antigen-specific responses both in vitro and in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据