期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 10, 页码 2207-2220出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20080300
关键词
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资金
- National Institutes of Health [AI-59635, AI-47822, GM-37734, HL-67674, AI-23990, AI-070813, CA-72074, AI37113-09, AI073198]
- Specialized Center of Research [HL-67674]
- Digestive Disease Center [DK-56339]
- Veterans Administration
- California HIV/AIDS Research Program [ID06-SD-206, TF06-SD-501]
- Serono Foundation
- Cancer Research Institute
- Deutsche Forschungsgemeinschaft
Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell-expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell-dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other silent or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1.
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