期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 11, 页码 2499-2506出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20080285
关键词
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资金
- Institut National du Cancer
- Association pour la Recherche sur le Cancer [3705]
- Ligue Nationale Contre le Cancer
- Fondation pour la Recherche Medicale
- Canceropole Grand Sud-Ouest
Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2; 11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro experiments revealed that miR- 125b was able to interfere with primary human CD34(+) cell differentiation, and also inhibited terminal (monocytic and granulocytic) differentiation in HL60 and NB4 leukemic cell lines. Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2; 11) translocation define a new clinicopathological entity.
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