期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 4, 页码 747-750出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20080066
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor ( CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.
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