期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 7, 页码 1523-1527出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20081210
关键词
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资金
- State of Washington, National Institutes of Health [AI060389, AI40035, DA024563, AI057568]
- Burroughs-Wellcome Fund
Retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) and proinflammatory cytokines. RLRs recognize distinct and overlapping sets of viruses, but the mechanisms that dictate this specificity were unknown. A new study now provides evidence for size-based discrimination of double-stranded RNA (dsRNA) by RLRs and suggests how host cells recognize a variety of RNA viruses.
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