期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 10, 页码 2187-2190出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20081736
关键词
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Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An orphan GPCR, CCRL2, has now been identified as an additional receptor for chemerin, providing a unique mechanism by which chemerin enhances inflammation. Furthermore, because recent data shows that chemerin-derived peptides possess antiinflammatory properties, chemerin may be involved in both the initiation and resolution of inflammation.
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