期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 205, 期 1, 页码 169-181出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20071164
关键词
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资金
- Wellcome Trust [R36731] Funding Source: Medline
Innate immunity is the first-line defense against pathogens and relies on phagocytes, soluble components, and cell-surface and cytosolic pattern recognition receptors. Despite using hard-wired receptors and signaling pathways, the innate immune response demonstrates surprising specificity to different pathogens. We determined how combinatorial use of innate immune defense mechanisms defines the response. We describe a novel cooperation between a soluble component of the innate immune system, the mannose-binding lectin, and Toll-like receptor 2 that both specifies and amplifies the host response to Staphylococcus aureus. Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways.
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