期刊
JOURNAL OF EXPERIMENTAL BOTANY
卷 65, 期 14, 页码 3859-3873出版社
OXFORD UNIV PRESS
DOI: 10.1093/jxb/eru054
关键词
Gene regulation; modelling; senescence; systems biology; transcriptional networks
资金
- BBRSC [BB/F005806/1]
- EPSRC [EP/I036575/1]
- Biotechnology and Biological Sciences Research Council [BB/F005806/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I036575/1] Funding Source: researchfish
- BBSRC [BB/F005806/1] Funding Source: UKRI
- EPSRC [EP/I036575/1] Funding Source: UKRI
The process of leaf senescence is induced by an extensive range of developmental and environmental signals and controlled by multiple, cross-linking pathways, many of which overlap with plant stress-response signals. Elucidation of this complex regulation requires a step beyond a traditional one-gene-at-a-time analysis. Application of a more global analysis using statistical and mathematical tools of systems biology is an approach that is being applied to address this problem. A variety of modelling methods applicable to the analysis of current and future senescence data are reviewed and discussed using some senescence-specific examples. Network modelling with a senescence transcriptome time course followed by testing predictions with gene-expression data illustrates the application of systems biology tools.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据