期刊
ONCOGENE
卷 35, 期 19, 页码 2413-2427出版社
SPRINGERNATURE
DOI: 10.1038/onc.2015.318
关键词
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资金
- Southern and Eastern Norway Regional Health Authority (Research Grant 'Genome Medicine of Colorectal Cancer') [2011024]
- Norwegian Cancer Society [PR-2007-0166, PR-2006-0442]
- KG Jebsen foundation
- Research Council of Norway [179571]
Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; however, the dysregulated splicing patterns found on a genome-wide scale have until recently been less well-studied. In this review, we provide an overview of aberrant RNA splicing and its regulation in cancer. We then focus on the executors of the splicing process. Based on a comprehensive catalog of splicing factor encoding genes and analyses of available gene expression and somatic mutation data, we identify cancer-associated patterns of dysregulation. Splicing factor genes are shown to be significantly differentially expressed between cancer and corresponding normal samples, and to have reduced inter-individual expression variation in cancer. Furthermore, we identify enrichment of predicted cancer-critical genes among the splicing factors. In addition to previously described oncogenic splicing factor genes, we propose 24 novel cancer-critical splicing factors predicted from somatic mutations.
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