期刊
JOURNAL OF EXPERIMENTAL BIOLOGY
卷 217, 期 19, 页码 3392-3395出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jeb.107664
关键词
Growth; Myotube formation; Transgenesis; Optimal fibre size hypothesis
类别
资金
- Marine Alliance for Science and Technology for Scotland (Scottish Funding Council) [HR09011]
- Canadian Biotechnology Strategy
Coho salmon (Oncorhynchus kisutch) transgenic for growth hormone (GH) show substantially faster growth than wild-type (WT) fish. We fed GH-transgenic salmon either to satiation (1 year; TF) or the same smaller ration of wild-type fish (2 years; TR), resulting in groups matched for body size to WT salmon. The myotomes of TF and WT fish had the same number and size distribution of muscle fibres, indicating a twofold higher rate of fibre recruitment in the GH transgenics. Unexpectedly, calorie restriction was found to decrease the rate of fibre production in transgenics, resulting in a 20% increase in average fibre size and reduced costs of ionic homeostasis. Genes for myotube formation were downregulated in TR relative to TF and WT fish. We suggest that muscle fibre size optimisation allows the reallocation of energy from maintenance to locomotion, explaining the observation that calorie-restricted transgenics grow at the same rate as WT fish whilst exhibiting markedly higher foraging activity.
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