期刊
JOURNAL OF EXPERIMENTAL BIOLOGY
卷 214, 期 7, 页码 1148-1152出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jeb.053496
关键词
oxidative stress; vertebrates; oxidative damage; antioxidants; modularity; network
类别
资金
- NERC [NE/G013888/1]
- Natural Environment Research Council [NE/G013888/1] Funding Source: researchfish
- NERC [NE/G013888/1] Funding Source: UKRI
Integration is a property of biological systems that refers to the extent to which their components are correlated through functional, structural, developmental or evolutionary interdependency. This study examined patterns of functional integration among different molecular components of the blood redox system (both plasma and red blood cells) in zebra finches (Taeniopygia guttata). Our results show a two cluster organization of the six measured variables: one cluster includes glutathione peroxidase in both red blood cells and plasma, thiol concentration in red blood cells and plasma hydroperoxides; the other cluster comprises a measure of the non-enzymatic antioxidant capacity in red blood cells and plasma. The interaction network amongst these variables shows (i) a strong positive connectivity among hydroperoxides, glutathione peroxidase and thiols, and (ii) negative connectivity between non-enzymatic and enzymatic antioxidants. Overall, our results also suggest strong and significant integration between the oxidative state of red blood cells and plasma.
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