期刊
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
卷 30, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1756-9966-30-58
关键词
Oncogene addiction Glioma; Molecular targeted therapy; Network addiction
类别
资金
- National Key Project of Science and Technology Supporting Programs [2007BAI05B08]
- National Natural Science Foundation of China [30772238, 30730035]
Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene, and is regarded as the 'Achilles heel' of the successful molecular targeted therapies in cancer. However, the role of oncogene addiction in gliomas has not been elucidated systematically. In this review, we summarize the current experimental and clinical evidence for the concept of oncogene addiction and describe the mechanisms explaining oncogene addiction in gliomas. And the clinical implications for oncogene addiction in molecular targeted therapy are further emphasized. In addition, we discuss future direction for defining complex oncogene addiction network through the integrated analysis of multiple platforms in the flow of genetic information in gliomagenesis.
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