期刊
JOURNAL OF EVOLUTIONARY BIOLOGY
卷 23, 期 12, 页码 2726-2730出版社
WILEY
DOI: 10.1111/j.1420-9101.2010.02115.x
关键词
allelic variation; antimicrobial activity; beta-defensin; great tit; innate immunity
资金
- European Research Council
Allelic variation in immune genes might result from, and contribute to, host-pathogen evolution. Functional allelic variation in the innate immune system has received little attention. Here, we investigate whether naturally occurring allelic variation within the avian innate immune system (beta-defensins) is associated with variation in antimicrobial activity. We tested differences in in vitro antimicrobial properties of the synthesized products of two alleles of avian beta-defensin 7, both of which occur at high frequency in natural populations of the great tit (Parus major). Only one allele strongly inhibited the growth of the gram-positive bacterium Staphylococcus aureus, but both alleles strongly inhibited growth of the gram-negative bacterium Escherechia coli. Our data demonstrate functional allelic variation in natural defensin genes, and we discuss how differences in efficacy against microbial species might contribute to maintaining this variation.
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