A current viewpoint on structure and evolution of collagens. I. Fibrillar collagens

This review summarizes current data of structure of the most representative group of superfamily of collagens-fibrillar collagens. The attention is focused on structural organization of individual domains and their functional role in the hierarchical stacking of collagen alpha-chains. There are presented characteristics of the main stages of biosynthesis and the supramolecular processing of fibrillar collagens. Also considered are some aspects of evolution of fibrillar collagens. The role of duplication of genome and genes, intergene combination, and translocation of exons in evolution of collagen genes is discussed.