期刊
OCULAR SURFACE
卷 13, 期 2, 页码 103-109出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtos.2014.10.003
关键词
barrier function; cornea; dry eye; epithelium; inflammation; signaling; tight junctions
资金
- [NMRC\CSA\2012\045]
By providing a physical and immunological barrier, the ocular surface serves the important function of protecting the vision apparatus. The barrier function keeps the cornea relatively dehydrated, preserving transparency for transmission of light. In many instances, dysfunction of this barrier leads to clinical diseases, such as dry eye, infectious keratitis, allergic keratoconjunctivitis, chemical injury, and persistent epithelial defects. Herein, we review the components of the epithelial barrier in the ocular surface, i.e., the transcellular and paracellular pathways, and describe the methodologies for measuring barrier function in vitro, in animals, and in clinical studies. The usefulness and limitations of these techniques are discussed. Recent studies in the regulation of individual tight junction proteins, the occludins, the zonula occludens, and the claudins, are also reviewed. Several potential interventional strategies based on the knowledge gained from these studies are noted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据