期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 153, 期 2, 页码 484-490出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2014.03.001
关键词
Hemerocallis citrina; Depression; Chronic unpredictable mild stress; Proinflammatory cytokines; Indoleamine 2; 3-Dioxygenase
资金
- National Natural Science Foundation of China [81202940]
- Science Research Foundation of ministry of Health AMP
- United Fujian Provincial Health and Education Project for Tacking the Key Research [WKJ-FJ-31]
Ethnopharmacological relevance: Hemerocallis citrina, a traditional herbal medicine, has been used for the improvement of behavioral and emotional status in Eastern-Asia countries. Previous studies in our laboratory demonstrated that ethanol extracts from Hemerocallis citrina (HCE) enhanced monoamines and brain-derived neurotrophic factor (BDNF) in depression-like model of rodents. Materials and methods: The present study extends earlier works on the role of anti-inflammation in regulating the antidepressant-like actions of HCE in rats exposed to chronic unpredictable mild stress (CUMS). Frontal cortex and hippocampal proinflammatory cytokines levels and indoleamine 2,3-dioxygenase (IDO) activity were measured after 4-week HCE treatment in the CUMS an control rats. Results: Chronic administration of HCE reversed the decreased sucrose preference in sucrose preference test. In addition, we also found that HCE inhibited interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression, as well as IDO activity in frontal cortex and hippocampus, which were increased in rats exposed to CUMS. Conclusions: Combining with our previous studies, our present finding suggests that the anti-inflammatory property of HCE might play a crucial role in its antidepressant-like effect through, at least in part, the restoration or improvement of monoaminergic and neurotrophin systems. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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