期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 148, 期 3, 页码 812-817出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2013.05.010
关键词
Passiflora edulis Sims; Cyclopassifloside; Antidepressant-like effect
资金
- National Natural and Science Foundations of China [30800090]
- 'Xibuzhiguang' project from the Chinese Academy of Sciences
- Key New Product Development of Yunnan Province [2010BC003]
Ethnopharmacological relevance: Various species of genus Passiflora have been used as traditional folk medicines owing to their sedative and anti-hypertensive properties. Passiflora edulis Sims most widely grown in the warm temperate for their fragrant fruits and their twigs and leaves are used as a folk medicine for treating both anxiety and nervousness in American countries. The present study was to evaluate the antidepressant-like effect and the active components of this plant. Materials and methods: The alcohol extracts of the stems (PES, 10 and 2 g/kg of the plant materials) and leaves (PEL, 10 and 2 g/kg of the plant materials) of Passiflora edulis Sims were orally administered to mice for 7 day. The animals were tested in the forced swim test (FST) and tail suspension test (TST). After behavioral assay of ethanol extract, phytochemical research of the stems and leaves (5.7 kg) of Passiflora edulis Sims were developed and further bioactive verification of monomeric compounds were conducted. Results: There are mainly cycloartane triterpenoids and their saponins isolated from this plant, including two new cycloartane triterpenoid saponins named cyclopassifloside XII (1) and XIII (2), together with six known cycloartane triterpenoids, cyclopassifloic acids B and E, cyclopassiflosides II, VI, IX and XI. The ethanol extract of Passiflora edulis Sims together with isolated compounds cyclopassiflosides IX and XI may possess antidepressant-like effect. Conclusions: Cycloartane triterpenoid was one of the main compositions of Passiflora edulis Sims and possess antidepressant-like activity. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved.
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