期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 144, 期 1, 页码 213-216出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2012.08.033
关键词
Antinociceptive; Dinoponera quadriceps; Proteic venom; Formicidae; Mice
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico
Ethnopharmacological relevance: In northeastern Brazil, Dinoponera (Ponerinae) ants macerate are used to treat ear ache and its sting, rheumatism, and back pain. Such a popular use is a relevant fact that called for experimental evaluation of the antinociceptive activity of Dinoponera venom. Materials and methods: Dinoponera quadriceps venom (DqV; 5-500 mu g/kg; i.v.) or morphine (3.4 mg/kg; s.c.) were evaluated in mice models of nociception (n=8 animals/group). Negative controls received sterile saline (0.9% NaCl; i.v.). Results: DqV showed 64% protein content and exhibited antinociceptive activity, without affecting motor function, in the tests: formalin (72%), writhing (52%), von Frey (71%) and hot plate (45%). The antinociceptive activity was abolished under protein denaturant conditions. Conclusions: This study provided the first demonstration of the antinociceptive property of Dinoponera quadriceps venom in mice models of chemical, mechanical and thermal nociception, corroborating the popular use and suggesting its potential therapeutic utilization in painful conditions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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