期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 143, 期 2, 页码 709-715出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2012.07.040
关键词
Geopropolis; Melipona scutellaris; Bioactive fractions; Antinociceptive; Cytokines; Pain; Propolis
资金
- FAPESP [2009/12352-3, 2010/20214-7]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [09/12352-3] Funding Source: FAPESP
Ethnopharmacological relevance: The pharmacological activity of geopropolis collected by stingless bees (important and threatened pollinators), a product widely used in folk medicine by several communities in Brazil, especially in the Northeast Region, needs to be studied. Objective: The aim of this study was to evaluate the antinociceptive activity of Melipona scutellaris geopropolis (stingless bee) using different models of nociception. Material and methods: The antinociceptive activity of the ethanolic extract of geopropolis (EEGP) and fractions was evaluated using writhing induced by acetic acid, formalin test, carrageenan-induced hypernociception, and quantification of IL-1 beta and TNF-alpha. The chemical composition was assessed by quantification of total flavonoids and phenolic compounds. Results: EEGP and its hexane and aqueous fractions showed antinociceptive activity. Both EEGP and its aqueous fraction presented activity in the mechanical inflammatory hypernociception induced by the carrageenan model, an effect mediated by the inhibition of IL-1 beta and TNF-alpha. The chemical composition of EEGP and its hexane and aqueous fractions showed a significant presence of phenolic compounds and absence of flavonoids. Conclusion: Our data indicate that geopropolis is a natural source of bioactive substances with promising antinociceptive activity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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