期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 141, 期 1, 页码 158-169出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2012.02.014
关键词
Huang-Lian-Jie-Du-Tang; Integral pharmacokinetic; Components classification; AUC-weighting approach; Correlation between pharmacokinetics and effect
资金
- National Natural Science Foundation of China [30873450]
- Ministry of Education [NCET-09-0163]
- Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education
- Priority Academic Program Development of Jiangsu Higher Education Institutions [ysxk-2010]
Ethnopharmacological relevance: Huang-Lian-Jie-Du-Tang (HLJDT, or Oren-gedoku-to in Japanese), an important multi-herb remedy in China and other Asia countries, has been used clinically to treat cerebral ischemia for decades. Materials and methods: According to the previous studies we have reported, an HPLC method was developed and validated for determination of berberine, palmatine, baicalin, baicalein and geniposide simultaneously in MCAO rat plasma after administration of HLJDT aqueous extract. A classified integral pharmacokinetic method was put forward after having compared the integrated concentration-time profile with that of single component. An AUC based weighting approach was used for integrated principle. Results: The results indicated the classified integral pharmacokinetic profile of index components from HLJDT could reveal the pharmacokinetic behavior of original components, and was corresponding to the holistic pharmacological effects of anti-ischemia with HLJDT. Conclusions: This study was aimed to explore an approach that could be applied to integrate the pharmacokinetic behavior of different components derived from HLJDT. The integrated pharmacokinetic results also provided more information for further understanding of the clinical cerebrovascular disease in use of HLJDT. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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