期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 130, 期 1, 页码 187-190出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2010.04.035
关键词
Salvia sclarea; Depression; Forced swim test; Serotonin; dopamine; Corticosterone
资金
- Korean Government [2009-0053624]
Aim of the study: The purpose of the present study was to screen aromatic essential oils that have antidepressant effects to identify the regulatory mechanisms of selected essential oils. Materials and methods: The antidepressant effects of essential oils of Anthemis nobilis (chamomile), Salvia sclarea (clary sage; clary), Rosmarinus officinalis (rosemary), and Lavandula angustifolia (lavender) were assessed using a forced swim test (FST) in rats. Rats were treated with essential oils by intraperitoneal injection or inhalation. Serum levels of corticosterone were assessed by enzyme-linked immunosorbent assay (ELISA). Results: Among the essential oils tested, 5% (v/v) clary oil had the strongest anti-stressor effect in the FST. We further investigated the mechanism of clary oil antidepression by pretreatment with agonists or antagonists to serotonin (5-HT), dopamine (DA), adrenaline, and GABA receptors. The anti-stressor effect of clary oil was significantly blocked by pretreatment with buspirone (a 5-HT1A agonist), SCH-23390 (a D-1 receptor antagonist) and haloperidol (a D-2, D-3, and D-4 receptor antagonist). Conclusions: Our findings indicate that clary oil could be developed as a therapeutic agent for patients with depression and that the antidepressant-like effect of clary oil is closely associated with modulation of the DAnergic pathway. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据