期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 121, 期 3, 页码 444-450出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2008.09.035
关键词
Dihuang Yinzi; Ischemic brain injury; Learning and memory; Apoptosis; Synaptophysin; Extracellular regulated kinase; Lactate dehydrogenase
资金
- National Natural Science Foundation of China [30400610, 30872735]
- Key Project of Natural Science Foundation of Chongqing [CSTC2008BA5002, CSTC2008BB5125]
- Scientific Innovation Foundation of Third Military Medical University [2007XG27]
Aim of the study: Traditional Chinese herb Dihuang Yinzi (DY) is well known to treat neurological diseases by traditional Chinese medical practitioners. This study is to elucidate its neuroprotective and anti-dementia role in ischemic brain injury. Materials and methods: The effects of DY on the pathohistological changes, lactate dehydrogenase (LDH) release, Morris water maze task, expression of synaptophysin (SYP) and extracellular signal-regulated protein kinase (ERK) of hippocampi of rats with ischemic brain injury were investigated. Results: This study showed that DY not only significantly decreased the number of TUNEL-positive cells but also reduced the LDH release of hippocampus of model rat. Morris water maze test showed that the ability of learning and memory of rats dramatically impaired after ischemic brain injury. However, DY ameliorated the impairment of learning and memory of ischemic rats. Furthermore, western blotting and immunohistochemical data showed that the expression of extracellular regulated protein and synaptophysin, which correlates with synaptic formation and function, decreased after ischemic insult. However, DY inhibited the reduction of ERK an SYP expression in a dose-dependent way. Conclusion: These results suggest that DY possesses neuroprotective and anti-dementia properties, at least in part, by preventing the loss of neural cells and synapses in ischemic brain injury. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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