期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 29, 期 5, 页码 749-752出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2013.848204
关键词
alpha-glucosidase; antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid
资金
- Internal Grant Agency, University of Veterinary and Pharmaceutical Sciences (IGA VFU) [6/2010/FaF, 7/2010/FaF]
Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
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