期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 30, 期 6, 页码 863-866出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2014.987137
关键词
Allosamidins; chitinase inhibitory activities; insecticidal and antifungal activities; synthesis
资金
- Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJ1400523, KJ060805]
- Natural Science Foundation Project of CQ CSTC [cstc2012jjA10101]
- Chongqing University Students' Training Project of Innovation and Undertaking [201410637020]
- Open Foundation from Tertiary College of Chongqing Engineering Research Center of Bioactive Substance
- Ministry of Education Engineering Research Center of Active Substance and Biotechnology, China [GCZX2012-2]
The pseudo-trisaccharide allosamidin 1 is a potent inhibitor of all family-18 chitinases, and it is confirmed to have insecticidal and antifungal activities. But the synthesis of allosamidins is very difficult, and it is a challengeable subject. Allosamidins were synthesized in solid-liquid phase, total solid-phase and total liquid-phase, respectively. Solid-liquid phase method realizes the partial solid-phase synthesis of allosamidins. Total solid-phase method greatly simplifies the purification process. Total liquid-phase method shortens the synthetic steps of allosamidins. The insecticidal and antifungal activities of allosamidins were also reported herein.
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