期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 29, 期 2, 页码 249-255出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2013.773994
关键词
Benzenesulfonamide; coumarin; cytochrome P450
资金
- Canadian Institutes of Health Research [MOP 102685]
- Canadian Breast Cancer Foundation
Two carbonic anhydrase IX (CA IX) inhibitors were radiolabeled with 18 F, and evaluated for imaging CA IX expression. Despite good affinity for CA IX and excellent plasma stability, uptake of both tracers in CA IX-expressing HT-29 tumor xenografts in mice was low. F-18-FEC accumulated predominately in the liver and nasal cavity, whereas a significant amount of F-18-U-104 was retained in blood. Due to minimal uptake in HT-29 tumors compared to other organs/tissues, these two tracers are not suitable for use for CA IX-targeted imaging.
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