期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 28, 期 6, 页码 1205-1210出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2012.723207
关键词
Antidiabetic drugs; 2,4-thiazolidinediones; imidazolidine-2,4-diones; 2-thioxo-imidazolidine-4-ones; chromonyl-2,4-thiazolidinediones; insulinotropic activity
资金
- Research Organization of Ankara University, Turkey [09B3336003]
Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001 mg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. In this series, the most potent compound is IVa having methyl group at N3 position of TZD ring.
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