相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Molecular dynamics simulations on the critical states of the farnesyltransferase enzyme
Sergio Filipe Sousa et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Synthesis and structure-activity relationships of novel benzofuran farnesyltransferase inhibitors
Kohsuke Asoh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Synthesis of potent antitumor and antiviral benzofuran derivatives
Shadia A. Galal et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
The Search for the Mechanism of the Reaction Catalyzed by Farnesyltransferase
Sergio Filipe Sousa et al.
CHEMISTRY-A EUROPEAN JOURNAL (2009)
Unraveling the Catalytic Pathway of Metalloenzyme Farnesyltransferase through QM/MM Computation
Ming-Hsun Ho et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2009)
Similarity-based SIBAR descriptors for classification of chemically diverse hERG blockers
Khac-Minh Thai et al.
MOLECULAR DIVERSITY (2009)
On Two Novel Parameters for Validation of Predictive QSAR Models
Partha Pratim Roy et al.
MOLECULES (2009)
Farnesyltransferase inhibitors: A detailed chemical view on an elusive biological problem
Sergio F. Sousa et al.
CURRENT MEDICINAL CHEMISTRY (2008)
Molecular dynamics analysis of farnesyltransferase: A closer look into the amino acid behavior
Sergio F. Sousa et al.
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY (2008)
QSAR Model for Alignment-Free Prediction of Human Breast Cancer Biomarkers Based on Electrostatic Potentials of Protein Pseudofolding HP-Lattice Networks
Santiago Vilar et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)
Enzyme flexibility and the catalytic mechanism of farnesyltransferase: Targeting the relation
Sergio F. Sousa et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2008)
On some aspects of variable selection for partial least squares regression models
Partha Pratim Roy et al.
QSAR & COMBINATORIAL SCIENCE (2008)
Analysis of zinc-ligand bond lengths in metalloproteins: Trends and patterns
Bruno Tamames et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
A caution regarding rules of thumb for variance inflation factors
Robert M. O'Brien
QUALITY & QUANTITY (2007)
Theoretical studies on farnesyltransferase: Evidence for thioether product coordination to the active-site zinc sphere
Sergio Filipe Sousa et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2007)
Principles of QSAR models validation: internal and external
Paola Gramatica
QSAR & COMBINATORIAL SCIENCE (2007)
Pharmacophore mapping of diverse classes of farnesyltransferase inhibitors
Tabish Equbal et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Exploiting the substrate tolerance of farnesyltransferase for site-selective protein derivatization
Uyen T. T. Nguyen et al.
CHEMBIOCHEM (2007)
Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential
Rieko Tanaka et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Theoretical studies on farnesyltransferase: The distances paradox explained
Sergio Filipe Sousa et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
Synthesis of novel benzofuran and related benzimidazole derivatives for evaluation of in vitro anti-HIV-1, anticancer and antimicrobial activities
Samia M. Rida et al.
ARCHIVES OF PHARMACAL RESEARCH (2006)
Farnesyl transferase inhibitors
AD Basso et al.
JOURNAL OF LIPID RESEARCH (2006)
Farnesyltransferase: Theoretical studies on peptide substrate entrance thiol or thiolate coordination?
SF Sousa et al.
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM (2005)
BCUT descriptors for predicting affinity toward A3 adenosine receptors
MP González et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
QSAR analyses of conformationally restricted 1,5-diaryl pyrazoles as selective COX-2 inhibitors: application of connection table representation of ligands
S Prasanna et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Farnesyltransferase - New insights into the zinc-coordination sphere paradigm: Evidence for a carboxylate-shift mechanism
SF Sousa et al.
BIOPHYSICAL JOURNAL (2005)
Inhibitors of farnesyltransferase: A rational approach to cancer chemotherapy?
IM Bell
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
J Ohkanda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
QSAR modelling of HIV-1 reverse transcriptase inhibition by benzoxazinones using a combination of P_VSA and pharmacophore feature descriptors
S Balaji et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
2D QSAR consensus prediction for high-throughput virtual screening. An application to COX-2 inhibition modeling and screening of the NCI database
N Baurin et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2004)
Structural characterization of the zinc site in protein farnesyltransferase
DA Tobin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation
JS Pickett et al.
BIOCHEMISTRY (2003)
Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs
L Eriksson et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2003)
The importance of being earnest: Validation is the absolute essential for successful application and interpretation of QSPR models
A Tropsha et al.
QSAR & COMBINATORIAL SCIENCE (2003)
Farnesyl protein transferase inhibitor ZARNESTRA (TM) R115777 - History of a discovery
M Venet et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2003)
Reaction path of protein farnesyltransferase at atomic resolution
SB Long et al.
NATURE (2002)
Beware of q(2)!
A Golbraikh et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2002)
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics
SB Long et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Farnesyl protein transferase inhibition: A novel approach to anti-tumor therapy. The discovery and development of SCH 66336
AK Ganguly et al.
CURRENT MEDICINAL CHEMISTRY (2001)
Application of BCUT metrics and genetic algorithm in binary QSAR analysis
H Gao
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2001)
Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase
KE Hightower et al.
BIOCHEMISTRY (2001)
Inhibitors of protein prenylation 2000
IM Bell
EXPERT OPINION ON THERAPEUTIC PATENTS (2000)
A widely applicable set of descriptors
P Labute
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2000)
Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei
FS Buckner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)