期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 27, 期 3, 页码 395-402出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2011.593176
关键词
Carbonic anhydrase; natural products; phenol; inhibition; isoform I and II
资金
- EU
- Karadeniz Technical University [2009.111.002.5]
- TUBITAK, BIDEB, TURKEY
Different natural products and secondary metabolites from mushrooms, teas, honeys, mosses, plants and seaweeds were investigated for their in vitro inhibitory effects on human carbonic anhydrase (hCA, E.C.4.2.1.1) isoforms I and II. Inhibition data were correlated with the total phenol content in the extract and investigated with the pure compounds believed to be responsible for this activity. Methanolic extracts were prepared for 17 such pure chemicals present in the natural products and for 41 diverse natural products. The IC50 values were in the range of 0.11-66.50 mu g/mL against hCA I and of 0.09-54.54 mu g/mL against hCA II, respectively. The total phenol content was in the range of 0.02-1318.96 (as milligrams of gallic acid equivalents) per gram of sample. These data offer new insights on possible novel classes of CA inhibitors based on natural products, possessing a range of chemical structures not present in the classical inhibitors with pharmacological applications, such as the sulfonamides and sulfamates.
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