期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 27, 期 6, 页码 886-891出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14756366.2011.638921
关键词
hypoxic tumors; superelectrophiles; fluorine chemistry; sultams
资金
- region Poitou-Charentes
- CNRS
- University of Poitiers
- EU
- University of Poitierregion
A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF5 from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.
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