期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 24, 期 3, 页码 876-882出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360802447917
关键词
Pyrazoline; antiviral; cytotoxic
Several substituted phenoxy acetic acid derived pyrazolines were synthesized by the reaction between2-{4-[3-(2,4-dihydroxyphenyl)-3-oxo-1-propenyl]-2-methoxyphenoxy} acetic acid and substituted acid hydrazides and were tested for their in vitro cytotoxicity and antiviral activity. None of the compounds showed any specific antiviral activity [50% antivirally effective concentration (EC50) >= 5-fold lower than minimum cytotoxic concentration]. The most cytotoxic of the series was 2-{4-[3-(2,4-dihydroxyphenyl)-1-(2-hydroxybenzoyl-4,5-dihydro-1H-5-pyrazolyl]-2-methoxyphenoxy}acetic acid (3(j)), with a minimum cytotoxic concentration of 0.16 mu g/mL in human embryonic lung (HEL) cells.
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