期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 23, 期 6, 页码 922-930出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360701810207
关键词
Morus lhou (S; ) Koidz; stem barks; tyrosinase; norartocarpetin; time-dependent inhibition
资金
- Technology Development Program for Agricultural and Forestry, Ministry of Agriculture and Forestry
- MOST/KOSEF [R15-2003-012-02001-0]
Five flavones displaying tyrosinase inhibitory activity were isolated from the stem barks of Morus lhou (S.) Koidz., a cultivated edible plant. The isolated compounds were identified as mormin (1), cyclomorusin (2), morusin (3), kuwanon C (4), and norartocarpetin (5). Mormin (1) was characterized as a new flavone possesing a 3-hydroxymethyl-2-butenyl at C-3. The inhibitory potencies of these flavonoids toward monophenolase activity of mushroom tyrosinase were investigated. The IC50 values of compounds 1-5 for monophenolase activity were determined to be 0.088, 0.092, 0.250, 0.135mM, and 1.2M, respectively. Mormin (1), cyclomorusin (2), kuwanon C (4) and norartocarpetin (5) exhibited competitive inhibition characteristics. Interestingly norartocarpetin (5) showed a time-dependent inhibition against oxidation of l-tyrosine: it also operated under the enzyme isomerization model (k5=0.8424min-1, k6=0.0576min-1, [image omitted]=1.354M).
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