期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 23, 期 6, 页码 1011-1017出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360701841251
关键词
Copper complexes; Schiff mono-bases; adducts; Lipophilicity; anti-inflammatory activity; antioxidant activity
Highly reactive radicals are implicated in many pathological conditions. The quest for radical scavengers or antioxidants, spans the previous decades. A new series of complexes of the type [Cu (dien) (2a-2tzn) Y2] and [Cu (dienXXY2) (2a-5mt)] and of the type [Cu (dptaS) Cl2] and [Cu (dptaS) Br2] (dptaS=1, 3-propanediamine) or Schiff mono-base of dipropylenetriamine with 2-thiophene-carboxaldehyde, has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit the carrageenin-induced rat paw edema (52.0-82.6%) and present important scavenging activity. Compound 6 is the most potent (82.6%) in the in vivo experiment. Lipophilicity-as RM values - has been determined. The results support that in general, adducts of the type [Cu (dienXXY2) (2a-5mt)] exhibit increased activity compared to the starting material of type [Cu (dienXXY2)]. An attempt to correlate the biological results with their structural characteristics and physicochemical parameters has been made.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据